Blatant Biology

the mass hydrolysis of proteins; a pathway that can (and is) tightly controlled to prevent excessive protein degradation

a pair of amino acids catalysing a reaction in an enzyme; can be conserved across enzymes catalysing the same reaction

the product left bound in the active site of a cysteine protease, after product 1 has left but before hydrolysis of a water molecule occurs to reset the enzyme to its original form

enzyme catalysing the removal of an amide functional group (on aspargine, aspartic acids, isoaspartic acid residues); alters the structure, function, and stability of a protein (potentially accelerating degradation)

genus of pathogenic bacteria, causing many challenging infections that are multi-drug resistant infections; infection may present with the signs and symptoms of other common illnesses (such as TB)

an identical protein found in a different species

a toxin protein from burkholderia pseudomallei, with a similar function to CNF1 from E. coli

a protein toxin produced by some pathogenic strains of E. coli

enzyme catalysing the deamination of glutamine amino acids

the maintenance of the 3D arrangment of catalytic residues in an enzyme, allowing the same reaction to be catalysed; frequently seen across enzymes with the same catalytic function

family of proteases isolated from papya, with wide ranging uses; has a catalytic triad

small GTPase protein, regulating actin dynamics in many cells; act as molecular switches, controlling organelle development, cytoskeletal dynamics, cell movement, ...; deamidated by CNF1

protein found in human cells, controlling GLUT4 translocation, cell growth, cytoskeletal reorganisation, ...; deamidated by CNF1

protein regulating the cell cycle, mediating cell division; deamidated by CNF1

inducing uncontrolled cell death by apoptosis in the host organism

large family of enzymes catalysing a wide range of metabolic reactions; all reactions involve the abstraction of a proton from a carbon adjacent to a carboxylic acid, and all have a divalent metal ion

metal ions that are positively charged and have a 2+ positive charge

bacterial enzyme catalysing the interconversin of enantiomers of mandelate through an enol intermediate

a molecule with a non-superimposable mirror image

a type of acid-base catalysis supported by a metal ion

a catalytic reaction supported by an acid or base

the protein domain within the enolase superfamily that contains the specificity pocket

member of the enolase superfamily, containing 2 proteins and 2 magnesium ions; catalyses the protonation of the enolate alpha-carbon (opposite reaction of beta-elimination)

the removal of the beta carbon, allowing the formation of a bond between the alpha and gamma carbons; catalysed by muconate lactonising enzyme

enzyme catalysing the interconversion between mandalate enantiomers, through an enol intermediate

a beta-barrel containing the active site residues of an enzyme, such as within muconate lactonising enzyme