Blatant Biology

enzyme involved in the type II fatty acid synthesis system, and potential target for novel antibiotics due to its presence in many bacterial species; bound by triclosan and triclocarban to provide bacteriostatic activity

ENR and BKR reductase enzyme grouping

an anion formed during the deprotonation of carbonyl compounds, formed during the ENR catalytic cycle

constituent enzyme of the type II FAS, catalysing an NADPH-dependent reduction; has the same Rossmann fold and conserved residues as ENR, but gives selectivity for the proton donation site

ENR inhibitor specifically targeting ENR, and a potential antibiotic drug that was toxic (due to a boron) and easy to develop resistance against

antibacterial and antifungal molecule, found in some consumer products (like soaps, toothpastes, detergents), but may disrupt hormonal development

the complex formed in bacteria after administering thienodiazaborine, inhibiting ENR activity; easy to develop mutations preventing the antimicrobial from binding while maintaining the biological function

enzyme catalysing the switching of position of a double bond, changing the tail structure of a fatty acid

enzyme complex catalysing the elimination of a water molecule and the insertion of a double bond

a protein structural motif where beta-sheets wrap around a central alpha-helix

a protein complex made of two identical proteins

the region of the protein the lengthening alkyl (fatty acid) chain extends into

the site for the pantetheine arm to enter before binding to the acyl chain to form a fatty acid

an analogue of vitamin B5; an intermediate in the catabolism of coenzyme A